Allergies arise from complex immunological imbalances, and patients presenting with allergic conditions require a detailed analysis and treatment of their endobiogenic terrain, including autonomic nervous system and hormonal function and, particularly, the role of the digestive system and gut. However, anti-allergic herbs can play a valuable part in the symptomatic treatment of such conditions. Several herbs have been used traditionally for their anti-allergic activity, but few have been investigated in human trials. One exception is the Indian herb Albizzia lebbeck, which was used in the indigenous system of medicine for respiratory problems. Earlier studies suggesting that Albizzia had an antihistamine effect were confirmed by a randomised controlled trial on patients with allergic conjunctivitis, who were treated with eye drops and capsules (orally) made from Albizzia bark concentrate. Although the relief of symptoms was slower than with steroid eye drops, it was more lasting, especially for those taking the Albizzia capsules as well as the eye drops – suggesting that Albizzia has a systemic and prolonged anti-allergic effect. Albizzia may be combined with other suitable herbs in anti-allergic formulations.